Debi DerryberryJames Isaac 'Jimmy' Neutron (voice)
Christian SlaterJet Fusion (voice)
Wendie MalickBeautiful Gorgeous (voice)
Michael Clarke DuncanCommander Baker (voice)
Tim CurryProfessor Calamitous (voice)
Dan CastellanetaProfessor Crank (voice)
Frank WelkerGoddard (voice)
Rob PaulsenCarl Wheezer / Monk / Voice / Clam (voice)
